Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus
نویسندگان
چکیده
منابع مشابه
Serious infection caused by group C streptococci.
Group C streptococci commonly cause infection in animals but only occasionally give rise to severe infection in man. We report here three cases of serious human infection due to this organism and discuss its pathogenicity in relation to the clinical manifestations of the disease.
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The majority of type III group B streptococcus (GBS) human neonatal infections are caused by a genetically related subgroup called III-3. We have proposed that a bacterial enzyme, C5a-ase, contributes to the pathogenesis of neonatal infections with GBS by rapidly inactivating C5a, a potent pro-inflammatory molecule, but many III-3 strains do not express C5a-ase. The amount of C5a produced in se...
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CYP4Fs were first identified as enzymes that catalyze hydroxylation of leukotriene B4 (LTB4). CYP4F18 has an unusual expression in neutrophils and was predicted to play a role in regulating LTB4-dependent inflammation. We compared chemotaxis of wild-type and Cyp4f18 knockout neutrophils using an in vitro assay. There was no significant difference in the chemotactic response to LTB4, but the res...
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Matched perianal swabs, rectal swabs, and faecal samples from a group of male homosexual patients attending a clinic for sexually transmitted disease were examined for the presence of group B streptococci (GBS). GBS recovery rates were as follows: perianal skin 31/115 (27%), rectal mucosa 18/72 (25%) and faeces 7/115 (6%). The recovery of GBS from faeces was similar to that obtained from faecal...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1991
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2730635